
DMSAK is a set of tools to manage multi-site Drupal installs. It has scripts to create and delete webs, update the codebase and modules, create and restore backups and others. It supports various Drupal code base versions simultaneously at the same server and allows code tweaking and customization only on specific webs.
Get the toolkit from DMSAK's repository at GitHub.

Start by customizing DMSAK for your setup:
# Copy dmsak-example.cfg to dmsak.cfg and edit the defaults.
DRUPAL_VERSION="6" # The default version of Drupal to use.
DRUPAL_DIR="/var/lib" # The directory where Drupal codebase and modules will be installed.
WEBS_DIR="/var/www" # The directory where the web directories are located.
BACKUP_DIR="/root" # Where to store backups.
TEMP_DIR="/tmp" # Directory for temporary files.
DB_HOST="localhost" # Database host.
DB_USER="root" # Database username.
DB_PASS="" # Database password (leave empty to enter password interactively).Next, install Drupal and required modules:
install-drupal.sh ../drupal-6.20.tar.gz
install-module.sh ../views-6.x-2.8.tar.gz
install-module.sh ../cck-6.x-2.9.tar.gz
...Create a web:
# Remember to create the vhost in Apache.
create-web.sh example.comNow you are ready to start building your new website!
To backup and restore a web:
# Backing up.
backup-web.sh example.com
# You can also use this to move or copy a site to a different server, but remember to install Drupal and required modules first.
restore-web.sh -b example.com-201102101530-backup.tar.gz example.com